1. Plan and coordinate activities of the various sectors in the National Response Strategic Framework;
2. Facilitate the engagement of all tiers of government and all sectors on issues of HIV/AIDS prevention, care and support;
3. Advocate for the mainstreaming of HIV/AIDS interventions into all sectors of the society;
4. Formulate policies and guidelines on HIV/AIDS;
5. Support HIV/AIDS research in the country;
6. Mobilize resources (local and foreign) and coordinate equitable application for HIV/AIDS activities;
7. Provide and coordinate linkages with the global community on HIV/AIDS;
8. Monitor and evaluate all HIV/AIDS activities in the country;
9. Facilitate the development and management of the policies and strategies of all sectors to ensure the human, financial and organizational resources to support the successful execution of the national HIV/AIDS response programme.
10. Establish, encourage and promote training programme for the employees of the Agency and other appropriate persons from public or private organizations;
11. Perform such functions as may, from time to time be assigned to it by the Government; and
12. Facilitate collaboration for the management of HIV and opportunistic infections.