The mandate of the National Agency for the Control of AIDS (NACA) derives primarily from the Act establishing the Agency part of which is reproduced below:

NATIONAL AGENCY FOR THE CONTROL OF HIV/AIDS ACT 2006
PART II – Functions and Powers of the Agency

6. (1) Subject to this Act the Agency shall perform the following functions:

• plan and coordinate activities of the various sectors in the National Response Strategic Framework;
• facilitate the engagement of all tiers of government and all sectors on issues of HIV/AIDS prevention, care and support;
• advocate for the mainstreaming of HIV/AIDS interventions into all sectors of the society;
• formulate policies and guidelines on HIV/AIDS;
• support HIV/AIDS research in the country;
• mobilize resources (local and foreign) and coordinate equitable application for HIV/AIDS activities;
• provide and coordinate linkages with the global community on HIV/AIDS;
• monitor and evaluate all HIV/AIDS activities in the country;
• facilitate the development and management of the policies and strategies of all sectors to ensure the human, financial and organizational resources to support the successful execution of the national HIV/AIDS response programme.
• establish, encourage and promote training programme for the employees of the Agency and other appropriate persons from public or private organizations;
• perform such functions as may, from time to time be assigned to it by the Government; and
• facilitate collaboration for the management of HIV and opportunistic infections.

      (2) In addition to the functions of the Agency as provided in sub-section (1) of this section, the Agency shall have power to:

• co-operate with persons and institutions undertaking research in Nigeria and in other countries;
• enter into contract within or outside Nigeria, with any persons, government, or institutions, and execute any contract, deed or any other document within or outside the Federal Republic or any foreign country for the purpose of combating HIV/AIDS;
• open and operate ordinary and domiciliary accounts for the Agency in recognized banking institutions;
• conditions and subject to the relevant provisions of this Act;
• pay gratuities and pensions to its officers and employees;
• develop and maintain an appropriate organizational structure;
• generally, enter into any contract or perform any act, whether within the Federal Republic of Nigeria or outside, as will in the opinion of the Board contribute towards the attainment of the Agency’s objectives; and
• establish State and Zonal Offices to coordinate the Agency’s functions.